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3M™ Emphaze™ AEX Series Hybrid Purifier

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3M™ Emphaze™ AEX Series Hybrid Purifier

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Reduces turbidity, HCP, DNA and bioburden.

Excellent throughput and mAb recovery.

Enhanced capture column performance and protection.

Overall Diameter (Metric)

Overall Height (Metric)

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Details

Highlights

Reduces turbidity, HCP, DNA and bioburden
Excellent throughput and mAb recovery
Enhanced capture column performance and protection
Substantial turbidity, DNA, HCP and bioburden reduction
Reduced surface area requirement of the downstream sterilizing grade membrane
May offer differentiated protection of the protein A column for enhanced contaminant clearance performance
All product components comply with United States Pharmacopeia (USP) Class VI 70°C Biological Reactivity Tests, in vivo

3M™ Emphaze AEX Hybrid Purifier is our single-use sterilisable and sanitisable. The all-synthetic purification media that contains a Q-functional anion exchange media and a fine particle and bioburden reduction membrane.

Remove impurities in biopharmaceutical process streams such as DNA, host cell proteins (HCP) and viruses with our all-synthetic, single use 3M™ Emphaze AEX Hybrid Purifier.

The composite purification media is comprised of three primary components: anion exchange nonwoven, microporous membrane, and membrane support. The anion exchange media is composed of four layers of polypropylene nonwoven with a covalently attached quaternary ammonium functional polymer.

The bioburden reduction membrane is a highly asymmetric polyamide membrane which has nine zones of decreasing pore size, spanning approximately a 20 X range, and terminating with a 0.2 μm rated qualifying layer. This is followed by a polypropylene nonwoven used as a support layer in the capsule.

Capsules

There are two primary capsule configurations for the Emphaze AEX Hybrid Purifier, Laboratory and Scale-up capsules:

The Laboratory capsule (BV8) has an 8ml bed volume.
The Scale-up capsules are constructed from a lenticular media cell design having bed volumes of 120 mls and 360 mls (BV 120 and BV 360 respectively).
The Production capsules are scaled to meet your manufacturing requirements and utilise manifolds in a holder for ease of use.

A full support package is available for 3M Emphaze AEX Hybrid Purifiers. This package includes Installation and Operation Guides, a Certificate of Quality and a Regulatory Support File.

Specifications

Details

Applications	Cell Culture Clarification, Chromatography and Column Protection, Adsorptive Depth Filtration, Bioburden Reduction, DNA Removal, Plasma Fractionation
Autoclavable	Yes
Brands	Emphaze™
Capsule Material	Glass Filled Polypropylene, Polypropylene, Polysulfone, Thermoplastic Elastomer (TPE), Fluorocarbon, Glass Filled Polypropylene Oxide, Silicone, Polystyrene
Dimensions (metric)	4.5 cm x 7.7 cm, 8.8 cm x 7.7 cm, 20.3 cm x 45.2 cm, 10.3 cm x 21.6 cm, 15.2 cm x 21.6 cm, 5.7 cm x 45.2 cm
Effective Filtration Area (metric)	0.23 cm², 1 cm², 1.6 cm², 4 cm², 25 m², 170 cm², 340 cm², 1020 m²
End Modification	3/4 in Sanitary Connectors, 1 1/2 in Sanitary Connectors, Luer Loc
Factory Integrity Tested	Capsule Leak Test
Fill Volume	0.55 mL, 1.4 mL, 2 mL, 3.4 mL, 5.5 L, 10.6 L, 13 L, 16 L
Filter Material	Functional Non-woven
Filter Technology	Anion exchange chromatography
Filter Type	Single Use
Flow Rate (metric)	0.4 Millilitre per Minute, 1.4 Millilitre per Minute, 8 Millilitre per Minute, 50 Millilitre per Minute, 100 Millilitre per Minute, 300 Millilitre per Minute, 680 Millilitre per Minute, 4700 Millilitre per Minute
Flux	210
Gamma Compatible	No
Gamma Sterilized	No
Gasket/O-ring Material	Fluorocarbon, Silicone
Industries	Life Sciences
Inlet Outlet Size	1.5", 3/4"
Inlet/Outlet Connections	3/4 in Sanitary Connectors, 1 1/2 in Sanitary Connectors, Luer Loc
Maximum Capacity	400
Maximum Operating Pressure (Metric)	2.4 bar, 2.8 bar, 3.1 bar, 3.4 bar
Maximum Operating Temperature (Celsius)	40 ℃
Membrane Type	Polyamide
Micron Rating	0.2 μm
Net Weight (Metric)	1 g, 1.1 g, 1.6 g, 3.4 g, 9 kg, 9.5 kg, 14.5 kg, 71 kg, 77 kg
Product Series	AEX
Series	Emphaze™ AEX Series, Emphaze™ AEX
Shelf Life	2 Year
Storage Temperature (Celsius)	0 °C - 30 °C
Temperature Range (Celsius)	0 °C - 40 °C
Units per Case	1.0, 2.0, 4.0

Dimensions and Classifications

Overall Diameter (Metric)	4.3 cm, 7.7 cm, 21.6 cm, 45.2 cm
Overall Height (Metric)	4.5 cm, 4.8 cm, 5.7 cm, 5.9 cm, 8.8 cm, 10.3 cm, 15.2 cm, 20.3 cm

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3M™ Emphaze™ AEX Series Hybrid Purifier

Details

Highlights

Specifications

Details

Dimensions and Classifications

Connect with us. We’re here to help.

Send Us a Message

Products of Interest

Thank you for your contacting 3M

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